I believe 50 -100 ml is the standard amount to get rid of with a 5-6 gallon batch and that would increase most likely if doing bigger batches. Im sure that commercial distillers have very sophisticated equipment for determining where to do cuts to get rid of the methanol but keep some heads and some tails so as not to lose too much product. I believe the #'s we use (50 -100ml) is overkill but its safer to do this and that small amount is silly to even think about worrying about as thats just 2 shots. From what I have read it is a poison but unless you were separating this and drinking just this the dilution would most likely just give you a headache but lets play it safe and use it as weed killer.