Maybe that would explain some of the whack shit france has done. J/k, but seriously though, I take your point, but I've found many references to the psychoactive properties of thujone. Perhaps some absinthes have more 'effects' than others due to a higher thujone content?
just from googling around I'm pretty convinced thujone is psychoactive. I wish I could rely on my own experience but I don't remember anything of the night when I drank a lot of absinthe, so can't say what exactly it did:
'Rice and Wilson found that a-thujone had comparative antinociceptive effects to codeine when injected subcutaneously in rats using the hot plate test ,ED50= 6.5 mg/kg,,5,. '
'Other cultures have discovered thujoneÃŒs intoxicating effects. In West Bengal Artemisia nilagirica ,a thujone containing plant, is smoked for its psychoactive effect and the Zuni smoke Artemisia caruhii as an analgesic,1,.'
'For a while it was hypothesized that thujone and tetrahydrocannabinol had the same site of action. This was believed to be true because of the similarities in their structures and effects,6,. But in 1997, it was shown that neither thujone nor wormwood binds to the canabinoid receptor,7,. Until recently it wasnÃŒt known wh at the mode of action for a-thujone was but a recent study done by Hold et al. at Berkeley have found the toxinÃŒs mode of action,8,.
They discovered that a-thujone is a Ãmodulator of the g-aminobutyric acid ,GABA, type A receptor.,8,Ó They compared a-thujone toxic effects to that of picrotoxinin, a GABAA receptor antagonist. It was found that they both had similar toxic effect and the toxicity in both was suppressed by diazepam, phenobarbital and ethanol. They also found that drosophila that had a single point mutation in the GABA receptor that made them resistant to dieldrin were also resistant to a -thujone. a-Thujone was found to be Ãa competitive inhibitor of [3H]EBOB binding, i.e., of the noncompetitive blocker site of the GABA-gated chloride channel.,8,Ó a-Thujone was also found to be a reversible modulator of the GABAA receptor in the dorsal root ganglia neurons. '
5. Rice, K.C; Wilson, R.S. Ã,-,-3-Isothujone, a small nonnitrogenous molecule with antinociceptive activity in mice.Ó Journal of Medicinal Chemistry 19.8 ,1976,: 1054-7.
6. Del Castillo, J; Anderson, M; Rubottom, GM. ÃMarijuana, absinthe, and the central nervous system.Ó Nature 253 ,1975,: 365-6.
7. Meschler, J; Marsh, C; Land, B; Howlett. ÃFailure of the active component of absinthe ,Artmisia absinthium, to bind the cannabinoid receptor.Ó International Cannabinoid Research Society, 1997 Meeting.
8. Hold, K; Sirisoma, N; Ikeda, T; Narahashi, T; Casida, J: Ãa-Thujone ,the active component of absinthe,: g-Aminobutyric acid type A receptor modulation and metabolic detoxification.Ó PNAS 97.8 ,2000,: 3826-31.